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. 2019 Dec 10;20(24):6223. doi: 10.3390/ijms20246223

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Inhibition of signaling pathways for interrupting of the T cell differentiation process. The differentiation of naïve-like T (T_N) cells and stem cell memory-like T (T_SCM) cells into T central memory-like (T_CM) cells, T effector memory-like (T_EM) cells, and highly differentiated T effector-like (T_Eff) cells can be interrupted by molecules inhibiting key metabolic and developmental pathways.