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. 2019 Dec 10;20(24):6223. doi: 10.3390/ijms20246223
1G 1st generation
2G 2nd generation
3G 3rd generation
4G 4th generation
AAV Adeno-associated virus
ACT Adoptive cell therapy
AICD Activation induced cell death
ALL Acute lymphoblastic leukemia
APCs Antigen presenting cells
BCAP B cell adaptor for phosphoinositide 3-kinase
BCMA B cell maturation antigen
BCR B cell receptor
BET Bromodomain and extra-terminal motif
CAR Chimeric antigen receptor
CLL Chronic lymphocytic leukemia
CTLA-4 Cytotoxic T-lymphocyte-associated Protein 4
DCs Dendritic cells
DLBCL Diffuse large B cell lymphoma
EMA European Medicines Agency
FDA Food and Drug Administration
GMP Good manufacturing practice
HLA Human leukocyte antigen
ICOS Inducible T cell costimulator
IL Interleukin
ITAM Immunoreceptor tyrosine-based activation motif
NHL Non-Hodgkin lymphoma
LAG-3 Lymphocyte-activation gene-3
PB Peripheral blood
PBMC Peripheral blood mononuclear cells
PD-1 Programmed cell death protein 1
PI3K Phosphoinositide 3-kinase
PMBCL Primary mediastinal B cell lymphoma
r/r relapsed/refractory
scFv Single chain variable fragment
TAA Tumor-associated antigen
TCR T cell receptor
TCM cell Central memory-like T cell
TEff cell Effector-like T cell
TEM cell Effector memory-like T cell
TGFβ Transforming growth factor β
Th cell T helper cell
TILs Tumor-infiltrating lymphocytes
TIM-3 T cell immunoglobulin and mucin-domain containing-3
TN cell Naïve-like T cell
TM Transmembrane
TRAC T cell receptor α constant
Treg cell Regulatory T cell
TRUCK T cells redirected for universal cytokine killing
TSCM cell Stem cell memory-like T cell
VIP Vasoactive intestinal peptide