Figure 5.

Protective effect of NC-5 on mice infected with A/FM/1/47 (H1N1) virus. The ICR mice were infected with influenza A virus (8 × LD₅₀), and ten mice in each group received placebo, NC-5 or oseltamivir phosphate (OS) twice daily for 5 days. (A) Survival rate. (B) Body weight. On day 5 p.i., five mice per group were sacrificed for lung pathology examinations. (C) Lung index. (D) Histological lung injury scores of mice in each group. (E) H & E staining of lung tissues (n = 5). Data are presented as the mean ± S.D. of three independent experiments, * p <0.05, ** p <0.01, *** p <0.001 compared with the placebo group.