Table 3.
Ref. | Year | Aim | HMGB1 |
---|---|---|---|
Ye et al. | 2011 | Role of HMGB1 and RAGE in stroke in T1DM rats and role of niaspan on pro-inflammatory proteins expression. | Increased HMGB1 expression after stroke in brains of STZ-induced MCAo rats. Niaspan treatment in STZ-induced MCAo rats decreased HMGB1 expression. |
Hu et al. | 2016 | Role of HMGB1 in stroke in T2DM rats and role of BMSCs in HMGB1 inflammation. | MCAo STZ/N-induced rats: increased HMGB1 and RAGE expression, increased BBB leakage, decreased functional outcome after stroke. Injection of BMSCs in STZ/N-induced rats: decreased HMGB1 and RAGE expression, attenuated BBB leakage and improved functional outcome after stroke, decreased inflammation after stroke. |