Table 2.
The top 10 genes in the protein–protein interaction (PPI) network of biological processes in gene ontology analysis.
| Time | 1 Week | 4 Weeks | 8 Weeks | Time | 1 Week | 4 Weeks | 8 Weeks | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GO | Brain Development (234 Genes) | Positive Regulation of Cell Population Proliferation (57 Genes) | Negative Regulation of Multicellular Organismal Process (73 Genes) | GO | Regulation of Postsynaptic Membrane Potential (58 Genes) | Ossification (24 Genes) | Extracellular Matrix Organization (25 Genes) | ||||||
| Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | ||
| 1 | Tp53 | 2.75 | Igf1 | 2.35 | Cd44 | 6.13 | 1 | Gria1 | −4.58 | Igf1 | 2.35 | Col1a1 | 13.87 |
| 2 | Casp3 | 2.40 | Ptprc | 2.64 | Timp1 | 6.30 | 2 | Grin2a | −3.68 | Spp1 | 10.97 | Col3a1 | 13.73 |
| 3 | Rhoa | 2.25 | Timp1 | 7.38 | Ccl2 | 2.66 | 3 | Grm5 | −3.18 | Mmp2 | 2.17 | Lum | 2.92 |
| 4 | Gnai1 | -2.84 | Cxcl12 | 2.13 | Tgfb1 | 2.05 | 4 | Gabra1 | −26.42 | Col1a1 | 15.05 | Postn | −2.40 |
| 5 | Syt1 | -20.35 | Mmp2 | 2.17 | Spp1 | 9.09 | 5 | Gabrg2 | −12.33 | Sparc | 2.12 | Fbln1 | 6.40 |
| 6 | Grin2a | -3.68 | Tgfb1 | 2.09 | Col3a1 | 13.73 | 6 | Grin2b | −2.39 | Igf2 | 25.06 | Mmp14 | 6.88 |
| 7 | Ccr5 | 3.14 | Lgals3 | 36.53 | Vim | 10.17 | 7 | Gabrb2 | −6.06 | Tgfb1 | 2.09 | Fmod | 7.47 |
| 8 | Myc | 5.49 | Rac2 | 2.59 | Dcn | 6.11 | 8 | Gria2 | −8.97 | Igfbp5 | 2.65 | Tgfb1 | 2.05 |
| 9 | Aif1 | 10.36 | Hmox1 | 2.39 | Cd74 | 15.20 | 9 | Grm1 | −2.47 | Ctsk | 3.21 | Lgals3 | 21.69 |
| 10 | Gnao1 | -5.73 | Igf2 | 25.06 | Anxa1 | 10.74 | 10 | Grik1 | −3.15 | Twist1 | 2.44 | Col18a1 | 3.03 |
| GO | Memory (76 Genes) | Wound Healing (32 Genes) | Response to Estradiol (27 Genes) | GO | Locomotory Behavior (91 Genes) | Negative Regulation of Cell Population Proliferation (41 genes) | Aging (34 Genes) | ||||||
| Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | ||
| 1 | Bdnf | −3.08 | Timp1 | 7.38 | Ccl2 | 2.66 | 1 | Gad1 | −3.54 | Igf1 | 2.35 | Ccl2 | 2.66 |
| 2 | Gria1 | −4.58 | Igf1 | 2.35 | Col1a1 | 13.87 | 2 | Scn1a | −9.28 | Cd44 | 7.93 | Tgfb1 | 2.05 |
| 3 | Grin2b | −2.39 | Sparc | 2.12 | Igf2 | 28.16 | 3 | Snap25 | −226.77 | Tgfb1 | 2.09 | Timp1 | 6.30 |
| 4 | Grin2a | −3.68 | Tgfb1 | 2.09 | Tgfb1 | 2.05 | 4 | Ppp1r1b | −4.62 | Sparc | 2.12 | Icam1 | 2.10 |
| 5 | Slc17a7 | −134.52 | Col1a1 | 15.05 | Vim | 10.17 | 5 | Adora2a | −2.65 | Tgfbr2 | 2.58 | Clu | 2.29 |
| 6 | Cnr1 | −3.65 | Dcn | 4.81 | Nqo1 | 2.16 | 6 | Mapk8 | −2.18 | Lgals3 | 36.53 | Gpx1 | 2.09 |
| 7 | Egr1 | −3.21 | Cd44 | 7.93 | Anxa1 | 10.74 | 7 | Gnao1 | −5.73 | Hmox1 | 2.39 | Nqo1 | 2.16 |
| 8 | Htr2a | −3.24 | Igf2 | 25.06 | Igfbp3 | 5.34 | 8 | Cacna1a | −5.10 | Bmp7 | 5.42 | Itgb2 | 2.36 |
| 9 | Snap25 | −226.77 | Col3a1 | 18.13 | Cd4 | 2.38 | 9 | Grm5 | −3.18 | Timp2 | 2.29 | Serping1 | 16.63 |
| 10 | Cck | −98.24 | Pf4 | 2.86 | Pdgfra | 2.33 | 10 | Grm1 | −2.47 | Gpc3 | 4.84 | Mbp | −3.01 |
| GO | Cellular Response to Drug (140 Genes) | Response to Estradiol (27 Genes) | Cellular Response to Lipid (43 Genes) | GO | Aging (138 Genes) | Cellular Response to Cytokine Stimulus (42 Genes) | Negative Regulation of Cell Population Proliferation (42 Genes) | ||||||
| Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | ||
| 1 | Tp53 | 2.75 | Igf1 | 2.35 | Ccl2 | 2.66 | 1 | Tp53 | 2.75 | Cxcl12 | 2.13 | Cd44 | 6.13 |
| 2 | Mapk8 | −2.18 | Col1a1 | 15.05 | Icam1 | 2.10 | 2 | Igf1 | 52.19 | Cd44 | 7.93 | Lgals3 | 21.69 |
| 3 | Ccl2 | 22.32 | Igf2 | 25.06 | Cd40 | 2.28 | 3 | Stat3 | 2.55 | Mmp2 | 2.17 | Ccl2 | 2.66 |
| 4 | Myc | 5.49 | Mmp2 | 2.17 | Cxcl13 | 2.31 | 4 | Agt | −18.17 | Spp1 | 10.97 | Tgfb1 | 2.05 |
| 5 | Icam1 | 6.54 | Tgfb1 | 2.09 | Tgfb1 | 2.05 | 5 | Mmp9 | 17.34 | Col1a1 | 15.05 | Tgfbr2 | 2.19 |
| 6 | Igf1 | 52.19 | Vim | 13.22 | Il18 | 2.36 | 6 | Bdnf | −3.08 | Ifitm1 | 34.44 | Aif1 | 2.16 |
| 7 | Hmox1 | 52.12 | Bmp7 | 5.42 | Spp1 | 9.09 | 7 | Icam1 | 6.54 | Cd74 | 10.83 | Fcgr2b | 2.12 |
| 8 | Rhoa | 2.25 | Igfbp3 | 2.12 | Col1a1 | 13.87 | 8 | Ccl2 | 22.32 | Ifitm3 | 4.49 | Gpc3 | 3.97 |
| 9 | Il18 | 10.22 | Pdgfra | 2.66 | Cxcl16 | 6.41 | 9 | Fos | −2.45 | Gbp2 | 4.47 | Tspo | 2.79 |
| 10 | Gnai2 | 2.31 | Igfbp2 | 14.03 | Pf4 | 3.40 | 10 | Hras | −2.11 | Cyba | 4.20 | Inhba | −2.18 |
| GO | Positive Regulation of Apoptotic Process (181 Genes) | Aging (34 Genes) | Positive Regulation of Cell Migration (39 Genes) | GO | Regulation of Cation Channel Activity (73 Genes) | Response to Lipopopysaccharide (30 Genes) | Inflammatory Response (31 Genes) | ||||||
| Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | ||
| 1 | Tp53 | 2.75 | Igf1 | 2.35 | Cxcl12 | 2.44 | 1 | Dlg4 | −8.41 | Igf1 | 2.35 | Ccl2 | 2.66 |
| 2 | Casp3 | 2.40 | Tgfb1 | 2.09 | Ccl2 | 2.66 | 2 | Cacna1a | −5.10 | Spp1 | 10.97 | Icam1 | 2.10 |
| 3 | Mapk8 | −2.18 | Timp1 | 7.38 | Icam1 | 2.10 | 3 | Cacng8 | −9.08 | Col1a1 | 15.05 | Timp1 | 6.30 |
| 4 | Myc | 5.49 | Mmp2 | 2.17 | Cxcl13 | 2.31 | 4 | Cacng7 | −4.68 | Fos | −2.66 | Cd44 | 6.13 |
| 5 | Tlr4 | 3.46 | Fos | -2.66 | Ccl19 | 3.69 | 5 | Shank1 | −28.89 | Tgfbr2 | 2.58 | Spp1 | 9.09 |
| 6 | Ccl2 | 22.32 | Clu | 2.19 | Col1a1 | 13.87 | 6 | Rasgrf1 | −14.10 | Sparc | 2.12 | Ccl19 | 3.69 |
| 7 | Mmp9 | 17.34 | Dcn | 4.81 | Anxa1 | 10.74 | 7 | Cacnb1 | −6.68 | Tgfb1 | 2.09 | Pf4 | 3.40 |
| 8 | Casp8 | 3.39 | Serping1 | 21.82 | Cd40 | 2.28 | 8 | Cacnb3 | −4.16 | Bmp7 | 5.42 | Itgb2 | 2.36 |
| 9 | Agt | −18.17 | Vim | 13.22 | Il18 | 2.36 | 9 | Cacnb2 | −2.62 | C3 | 8.25 | Il18 | 2.36 |
| 10 | Anxa5 | 2.05 | Ucp2 | 2.75 | Aif1 | 2.16 | 10 | Cacnb4 | −4.46 | Cyba | 4.20 | Cxcl13 | 2.31 |
| GO | Regulation of Synaptic Vesicle Exocytosis (59 Genes) | Response to Drug (64 Genes) | Cell Adhesion (44 genes) | GO | Cellular Response to Organic Cyclic Compound (166 Genes) | Nervous System Development (90 Genes) | Wound Healing (28 Genes) | ||||||
| Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | Gene | Fc | ||
| 1 | Syt1 | −20.35 | Mmp2 | 2.17 | Cd44 | 6.13 | 1 | Casp3 | 2.40 | Cd44 | 7.93 | Timp1 | 6.30 |
| 2 | Stxbp1 | −7.15 | Igf1 | 2.35 | Spp1 | 9.09 | 2 | Stat3 | 2.55 | Igf1 | 2.35 | Col1a1 | 13.87 |
| 3 | Stx1a | −23.65 | Col1a1 | 15.05 | Cxcl12 | 2.44 | 3 | Igf1 | 52.19 | Mmp2 | 2.17 | Tgfb1 | 2.05 |
| 4 | Rab3a | −23.39 | Tgfb1 | 2.09 | Icam1 | 2.10 | 4 | Myc | 5.49 | Spp1 | 10.97 | Dcn | 6.11 |
| 5 | Cplx1 | −62.03 | Fos | -2.66 | Col3a1 | 13.73 | 5 | Bdnf | -3.08 | Cxcl12 | 2.13 | Cd44 | 6.13 |
| 6 | Syt2 | −8.04 | Hmox1 | 2.39 | Lamb2 | 2.15 | 6 | Ccl2 | 22.32 | Gfap | 8.65 | Col3a1 | 13.73 |
| 7 | Vamp1 | −14.02 | Igf2 | 25.06 | Itgb4 | 10.95 | 7 | Rhoa | 2.25 | Col3a1 | 18.13 | Igf2 | 28.16 |
| 8 | Cplx2 | −18.49 | Sparc | 2.12 | Thbs2 | 3.49 | 8 | Egr1 | −3.21 | Fos | −2.66 | Postn | −2.40 |
| 9 | Syp | −44.39 | Vim | 13.22 | Tgfbr2 | 2.19 | 9 | Icam1 | 6.54 | Vim | 13.22 | Vim | 10.17 |
| 10 | Camk2a | −139.81 | Gpx1 | 2.17 | Postn | -2.40 | 10 | Actb | 2.25 | Mmp14 | 6.52 | Pf4 | 3.40 |