Table 3.

Diagnostic indices for the biomarkers panel.

Indexes	Biomarkers Panel	8-OHdG	8-OHdG/2-dG
AUC (95% CI)	0.843 (0.750–0.936)	0.794 (0.687–0.902)	0.66 (0.536–0.785)
Sensitivity (%, 95% CI)	78.4 (65.4–87.5)	77.4 (64.5–86.5)	66.0 (52.6–77.3)
Specificity (%, 95% CI)	85.2 (67.5–94.1)	74.1 (55.3–86.8)	66.7 (47.8–81.4)
PPV (%, 95% CI)	90.9 (78.8–96.4)	85.4 (72.8–92.8)	79.5 (65.5–88.8)
NPV (%, 95% CI)	67.6 (50.8–80.9)	62.5 (45.3–77.1)	50.0 (34.5–65.5)
LR+ (95% CI)	5.29 (2.12–13.23)	2.98 (1.55–5.74)	1.98 (1.12–3.49)
LR− (95% CI)	0.25 (0.15–0.43)	0.31 (0.18–0.53)	0.51 (0.33–0.78)
DOR (95% CI)	20.91 (5.97–73.28)	9.76 (3.33–28.59)	3.89 (1.46–10.38)