Table A1.
Genes implicated in autism susceptibility that fall into more than one category.
| Categories of Genes | Total Number | Elements |
|---|---|---|
| FMRP target ∩ vitamin D-sensitive ∩ mTOR signaling pathway ∩ mTOR-modulated | 3 | PTEN APC DOCK1 |
| FMRP target ∩ mTOR signaling pathway ∩ mTOR-modulated | 6 | SYNGAP1 TSC2 CTNNB1 GSK3B EEF1A2 CUL7 |
| FMRP target ∩ vitamin D-sensitive ∩ mTOR-modulated | 17 | SYT1 SMARCC2 KDM5C DMXL2 UBE3B CLASP1 PCDH10 MAP2 HCFC1 ATP1A1 ANKRD11 SEZ6L2 RERE UPF2 LRBA MED12 NCKAP5L PCDH10 |
| FMRP target ∩ vitamin D-sensitive ∩ mTOR- pathway | 1 | DGKZ |
| Vitamin D-sensitive ∩ mTOR signaling pathway ∩ mTOR-modulated | 2 | XPO1 CCT4 |
| FMRP target ∩ mTOR-modulated | 61 | KMT2E CHD8 ARHGAP32 ATP1A3 DPYSL2 GNAS EP400 CAMTA1 AKAP9 PLXNB1 MED13 CHD3 TRIP12 DHX30 DYNC1H1 ARHGAP33 EHMT1 SLC12A5 IQSEC2 HUWE1 UBR5 BRD4 DLG4 NSD1 ATP2B2 CHD5 STXBP1 MYH10 ITPR1 CUX1 TAOK2 GRM4 ANK3 SETD5 SMARCA2 UBE3C MAGED1 KAT6A AGAP2 APP HDLBP TNRC6B NCKAP1 PHRF1 LEO1 TOP3B CHD7 EXOC6B USP7 SETDB1 SLC27A4 SND1 SETDB2 AHI1 MTR CC2D1A KIF13B SGSH GGNBP2 MCM6 ROBO1 |
| FMRP target ∩ mTOR signaling pathway | 7 | PRKCB MAPK1 PTPN11 MTOR CREBBP NF1 TAF1 |
| FMRP target ∩ vitamin D-sensitive | 40 | KCNMA1 MED13L NR2F1 WDFY3 SBF1 PACS1 SMARCA4 CAMK2A SPARCL1 KDM4B CACNA1B DLGAP3 TCF4 PDE4B CHKB SRGAP3 DLGAP1 ZNF462 TCF20 KCNQ3 DLGAP2 HIVEP3 KCND2 KIF21B DOCK4 SHANK3 NTRK3 ARID1B CUX2 DAPK1 PRICKLE2 NEO1 CCDC88C MYO9B CASK VLDLR NUP133 SSRP1 TSHZ3 NUAK1 |
| mTOR-modulated ∩ mTOR-pathway | 6 | EIF4E TSC1 CDKN1B PIK3R2 YY1 TBC1D7 |
| Vitamin D-sensitive ∩ mTOR-modulated | 49 | VDR RAB2A DLG1 ELP4 SLC33A1 STX1A MTHFR CAPRIN1 SLC16A7 CD99L2 NELL1 STAG1 LAT MEIS2 AZGP1 MPP6 ASS1 ABAT THBS1 BCAS1 DMPK ARHGAP5 OTX1 PHF8 MTF1 HDAC3 BCKDK ASTN2 SLC39A11 FGFR2 NRCAM FHIT MBD4 ETFB SLC35B1 ESR1 SIN3A SUCLG2 CSNK1D PHB PRICKLE1 MTX2 NAA15 SGSM3 HNRNPU BAIAP2 ALDH5A1 STK39 EXOC6 |
| Vitamin D-sensitive ∩ mTOR signaling pathway | 7 | CSNK1E SLC7A5 WNT2 DYRK1A DVL1 HRAS RPS6KA2 |