Table 3.
Examples of antibody applications in different areas of molecular science.
| Antibodies | Examples/Uses | Antibody Type | References |
|---|---|---|---|
| Research | Target Recognition | ||
| CD14, CD20, CD34/ELISA, ICC, WB, FC | Peptide Ab (MAb) | [63,64,65] | |
| Diagnostics | Target Quantification | ||
| Isocitrate dehydrogenase, B-Raf, Epidermal growth factor receptor/IHC | Peptide Ab (MAb) | [66,67,68] | |
| melanoma Glycoprotein B, Herpes simplex encephalitis/IHC, ELISA | Peptide Ab (MAb) | ||
| Therapeutics | Target Neutralization | ||
| Rhesus-D Ig/rhesus syndrome prophylaxis | PAb (Sp IVIG) | [69] | |
| Anti-toxins/botulism | PAb (Sp IVIG) | [70,71] | |
| Rituximab/lymphoma, Ocrelizumab/multiple sclerosis | MAb (recombinant), chimeric | [72,73] | |
| Infliximab/rheumatoid arthritis | MAb (recombinant), chimeric | [74] | |
| Nivolumab/malignant melanoma | MAb (recombinant), human | [75] | |
| Panitumumab/EGFR metastatic colorectal carcinoma | MAb (recombinant), human | [76] | |
| Daclizumab/allograft rejection | Mab (recombinant), humanized | [77] | |
| HpHbR Ab-PBD conjugate/African trypanosomiasis treatment (mouse model) | MAb-drug conjugate | [78] | |
| Vaccines | |||
| MMR live attenuated viruses vaccine/measles, mumps, rubella prophylaxis | PAb in vivo | [79] | |
| DiTePePolHiB SU vaccine/diphtheria-tetanus-pertussis-polio-hemophilus prophylaxis | PAb in vivo | [80,81,82] | |
| HPV SU vaccine/cervix cancer prophylaxis | PAb in vivo | [83,84] |
CD: cluster of differentiation. DiTePePolHiB SU: Diphteria-Tetanus-Pertussis-Polio-Hemophilus influenzae B subunit vaccine. EGFR, epidermal growth factor receptor. ELISA: enzyme-linked immunosorbent assay. FC: flow cytometry. HpHbR: haptoglobin-hemoglobin receptor. IVIG: Intravenous immunoglobulin. HPV: human papilloma virus. ICC: immunohistochemistry. IHC: immunohistochemistry. MAb: monoclonal antibody. MMR: Measles-mumps-rubella. PAb: polyclonal antibody. PBD: pyrrolobenzodiazepine. Sp: Specific. SU: subunit. WB: Western blotting.