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Matrix metalloproteinases (MMPs) regulate shedding of betaglycan. The 1 × 105 93RS2 cells/well were incubated with GM6001 (10 µM) for 24 h (A) and 48 h (B). Supernatants were analyzed for sBG by ELISA. GM6001 attenuated shedding of BG significantly. Each bar represents the mean ± SEM of 3 independent experiments performed in duplicate. Student’s t-test was used for statistical analysis; *p ≤ 0.05, **p < 0.01.
