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. 2019 Dec 16;20(24):6339. doi: 10.3390/ijms20246339

Table 4.

Over representation analysis of all identified metabolites in oEVs against pathway associated metabolite sets. The associated bar chart visualization of this analysis is shown in Figure 4.

Pathway Associated Metabolite Sets 1 Implicated Metabolites 2 Total 3 Hits 4 Raw p 5 Holm p 6 FDR 7
Glycine and serine metabolism Creatine, Glycine, L-glutamic acid, L-alanine, L-threonine, L-methionine 59 6 7.82 × 10−4 0.0766 0.0766
Arginine and Proline Metabolism Creatine, Glycine, L-glutamic acid, L-proline, Succinic acid 53 5 0.00332 0.322 0.137
Alanine metabolism Glycine, L-glutamic acid, L-alanine 17 3 0.00421 0.404 0.137
Valine, Leucine and Isoleucine degradation L-glutamic acid, L-isoleucine, Succinic acid, L-leucine, L-valine 60 5 0.00575 0.546 0.141
Glutathione Metabolism Glycine, L-glutamic acid, L-alanine 21 3 0.0078 0.734 0.146
Carnitine Synthesis L-carnitine, Glycine, Succinic acid 22 3 0.00892 0.829 0.146
Glutamate Metabolism Glycine, L-glutamic acid, L-alanine, Succinic acid 49 4 0.0152 1 0.212
Phosphatidylethanolamine biosynthesis Choline, Ethanolamine 12 2 0.0234 1 0.267
Ketone Body Metabolism Succinic acid, Acetone 13 2 0.0273 1 0.267
Glucose-Alanine Cycle L-glutamic acid, L-alanine 13 2 0.0273 1 0.267
Phosphatidylcholine biosynthesis Choline, Ethanolamine 14 2 0.0314 1 0.28

1 Only pathway associated metabolite sets with p < 0.05 are shown in the table; 2 Implicated metabolites from oEVs in the associated metabolite set; 3 Total number of metabolites in the metabolite set; 4 Hits: number of metabolites from oEVs involved in the metabolite set; 5 Raw p: original p value calculated from the enrichment analysis; 6 Holm p: adjusted raw p value by the Holm–Bonferroni method; 7 FDR: false discovery rate.