Table 4.
Pathway Associated Metabolite Sets 1 | Implicated Metabolites 2 | Total 3 | Hits 4 | Raw p 5 | Holm p 6 | FDR 7 |
---|---|---|---|---|---|---|
Glycine and serine metabolism | Creatine, Glycine, L-glutamic acid, L-alanine, L-threonine, L-methionine | 59 | 6 | 7.82 × 10−4 | 0.0766 | 0.0766 |
Arginine and Proline Metabolism | Creatine, Glycine, L-glutamic acid, L-proline, Succinic acid | 53 | 5 | 0.00332 | 0.322 | 0.137 |
Alanine metabolism | Glycine, L-glutamic acid, L-alanine | 17 | 3 | 0.00421 | 0.404 | 0.137 |
Valine, Leucine and Isoleucine degradation | L-glutamic acid, L-isoleucine, Succinic acid, L-leucine, L-valine | 60 | 5 | 0.00575 | 0.546 | 0.141 |
Glutathione Metabolism | Glycine, L-glutamic acid, L-alanine | 21 | 3 | 0.0078 | 0.734 | 0.146 |
Carnitine Synthesis | L-carnitine, Glycine, Succinic acid | 22 | 3 | 0.00892 | 0.829 | 0.146 |
Glutamate Metabolism | Glycine, L-glutamic acid, L-alanine, Succinic acid | 49 | 4 | 0.0152 | 1 | 0.212 |
Phosphatidylethanolamine biosynthesis | Choline, Ethanolamine | 12 | 2 | 0.0234 | 1 | 0.267 |
Ketone Body Metabolism | Succinic acid, Acetone | 13 | 2 | 0.0273 | 1 | 0.267 |
Glucose-Alanine Cycle | L-glutamic acid, L-alanine | 13 | 2 | 0.0273 | 1 | 0.267 |
Phosphatidylcholine biosynthesis | Choline, Ethanolamine | 14 | 2 | 0.0314 | 1 | 0.28 |
1 Only pathway associated metabolite sets with p < 0.05 are shown in the table; 2 Implicated metabolites from oEVs in the associated metabolite set; 3 Total number of metabolites in the metabolite set; 4 Hits: number of metabolites from oEVs involved in the metabolite set; 5 Raw p: original p value calculated from the enrichment analysis; 6 Holm p: adjusted raw p value by the Holm–Bonferroni method; 7 FDR: false discovery rate.