Figure 2.

Binding partners of mutant p53-TAp63 and mutant p53-TAp73 complexes. In this figure, binding partners of the mutant p53-p53 family member complexes are depicted. The functional consequence of the binding of each partner on p63 or p73 transcriptional function is shown. Binding partners of the mutant p53-p53 family member complex either promote or inhibit the function of p63 or p73. Some binding partners promote the complex formation between mutant p53 and the p53 family members, sequestering those family members and preventing them from mediating their transcription function. Other proteins prevent the binding of mutant p53 to family members, leading to the release of p63 or p73 and subsequent initiation of transcription, resulting in apoptosis and inhibition of invasion and metastasis. Of note, in most cases, it is not known to which molecule the interaction partners bind. This means that the exact position in which the interaction partner is depicted in this model might not be a precise reflection of the complex in reality. In addition, many different binding partners are shown to interact with the complexes, but it is currently unknown if this co-occurs or whether the binding is mutually exclusive.