Table 1.

Inhibitors affecting the mutant p53-TAp63 or mutant p53-TAp73 complex and function of p63 or p73.

Drug	Action	Consequence	Tissue/Cells	Ref.
RETRA	Inhibit mutant p53-p73 interaction	Restore TAp73 function	Various cancer cells	[84]
Peptide aptamers	Inhibit mutant p53-p73 interaction	Restore TAp73 function	Tumour cells	[85]
SIMPs *	Inhibit mutant p53-p73 interaction	Restore TAp73 function	Various cancer cells	[86]
Benzyl isothiocyanate	Inhibit mutant p53-p73 interaction	Upregulate and restore function of TAp73, induce LKB1	Breast cancer cells	[87]
LEM2	Inhibit mutant p53-p73 interaction	Restore TAp73 function and prevent MDM2 mediated degradation	Neuroblastoma cancer cells	[88]
Prodigiosin	Inhibit mutant p53-p73 interaction	Restore TAp73 function	Various cancer cell lines	[89]
NSC59984	Inhibit mutant p53-p73 interaction	Restore TAp73 function	Colorectal cancer cells	[90]
PDGFR-β inhibition	Downstream of mutant p53-p73-NF-Y	Prevent PDGFR-β signalling	Pancreatic cancer	[91]
Curcumol	Upregulation p73 + target genes	Enhance TAp73 function	Triple negative breast cancer	[92]
miR-3158	Downstream of mutant p53/p73	Reactivate the miR-3158 signalling pathway	Breast cancer cells	[93]
Pramlintine	Downstream of mutant p53/p63	Inhibit the function of amylin	Lymphomas	[30]
Tamoxifen/inhibition ER β1	Downstream of mutant p53-p63/ER β1	Prevent transcription of GOF associated genes	Triple negative breast cancer cells	[94]
miR-130b	Downstream of mutant p53-p63	Reactivate the miR-130b signalling pathway	Ovarian cancer cells	[95]
Let7i	Downstream of mutant p53-p63	Reactivate the let7i signalling pathway	Breast cancer cells	[96]
Inhibition of TGF β or RAS signaling	Prevent TGF β-induced mutantp53-p63-pSMAD interaction	Reactivate TAp63 function	Various cancer cells	[59]
Inhibition of EGFR, c-MET, ROCK	Downstream of mutant p53-p63	Prevent invasion induced by loss of TAp63 function	Various cancer cells	[47,97]

* Short Interfering Mutant p53 Peptides.