Figure 2.

Original recording demonstrating the potentiating effect of S1P on PE-induced vasoconstriction in TA segments prepared from WT mice. “PE”, “S1P”, and “K⁺”denotes administration of the corresponding compounds and 124 mM potassium, respectively. “W” denotes wash-out with fresh Krebs solution. PE was administered at increasing concentrations (0.1 nM–10 µM) enabling the evaluation of the dose-response-relationship. Between two PE administrations, S1P (5 µM) was applied for 20 min followed by W.