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The role of NF-κB signaling in chondrogenic development. (A) The classical NF-κB signaling pathway regulates apoptosis (gray cells) in proliferative and prehypertrophic chondrocytes. (B) The alternative NF-κB pathway regulates chondrocyte proliferation and differentiation and maintains endochondral ossification. Also shown are the resting zone (RZ), proliferating zone (PZ), prehypertrophic zone (PHZ), hypertrophic zone (HZ), and trabecular bone (TB).
