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. 2019 Dec 16;20(24):6335. doi: 10.3390/ijms20246335

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The proposed model for the mechanism of iNOS-induced endothelial cell apoptosis and hemorrhage. GCRV infects the vascular endothelial cell and activates the expression of iNOS. A large quantity of NO was produced by iNOS and leads mitochondrial apoptosis to release cytochrome C. The cytochrome C activates the caspase process and leads the vascular endothelial cell apoptosis. The hemorrhage happened when vascular endothelial cells apoptosis. SMT can inhibit the activity of iNOS to produce NO.