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Scheme of synthesis of compounds 16–22. Coupling of compounds 8–14 with the benzothiazole–linker 15 was performed according to the literature [30]. Compounds: 16 (n = 0, R1–R4 = H); 17 (n = 0, R1 = O CH3, R2-R3 = H, R4 = O CH3); 18 (n = 0, R1 = O CH3, R2 = H, R3 = O CH3, R4 = H); 19 (n = 0, R1 = H, R2 = O CH3, R3 = H, R4 = O CH3); 20 (n = 1, R1–R2 = H, R3 = O CH3); 21 (n = 1, R1–R2 = H, R3 = CF3); 22 (n = 1, R1 = F, R2–R3 = H).
