Figure 1:

The GABA_AR α6β3γ2 Subtype^a

^aThe GABA_AR α6β3γ2 subtype is a pentameric ligand-gated chloride channel comprised of two α6, two β3 and one γ2 subunits. PQs, like 8b, mediate their effects at the α6+β3- interface (PQ Site) as positive allosteric modulators and act at the DI-Bz site (α6+γ2- interface) as null modulators. The PQ site, the DI-Bz binding site and the endogenous ligand (GABA) binding sites at the β3+α6- interfaces are displayed. Image modified from Jacob et al., Nature Reviews Neuroscience, 2008.