Figure 10:

Pharmacokinetic profiles in plasma and brain following oral gavage (PO) or IV administration of 8a (A) and 8b (B)^a

^aPlasma and brain absolute bioavailability profiles of 8a (A), and 8b (B) presented in respective graphs as F_systemic and F_brain is calculated as a ratio of respective AUC_0–24 values obtained after IV and oral gavage (PO) administration of a 2 mg kg⁻¹ dose (n = 3 per time point). C_max = maximum concentration in brain or plasma; t_max = time of maximum concentration in brain or plasma; t_1/2 = terminal elimination half-life; AUC_0–24 = area under the concentration versus time curve from zero to last measurable time point.