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GABAAR α6β3γ2 subtype selectivity of the lead ligands: 8a, 8n and 8ia
aConcentration response curves of the change of GABA EC3 currents (modulation, referenced to 100% for the EC3 current) by increasing compound concentrations. 8a (A), 8n (B) and 8i (C) preferentially modulate GABA currents of α6β3γ2 receptors.
