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. Author manuscript; available in PMC: 2020 Jan 3.
Published in final edited form as: J Med Chem. 2018 Mar 6;61(6):2422–2446. doi: 10.1021/acs.jmedchem.7b01664

Figure 7:

Figure 7:

The effect of N-hetero substitution onto the “A-ring” or “D-ring” of the lead ligands on GABAAR α6β3γ2 subtype activitya

aElectrophysiological experiments exhibited that N-hetero substitution onto the “A-ring” or “D-ring” of the parent ligands decreased the activity of the ligands for the α6β3γ2 subtype. 8a related ligands (A). 8n related ligands (B). 8k related ligands (C).