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. Author manuscript; available in PMC: 2020 Jan 3.
Published in final edited form as: J Med Chem. 2018 Mar 6;61(6):2422–2446. doi: 10.1021/acs.jmedchem.7b01664

Figure 9:

Figure 9:

Pharmacokinetic Profiles of Select Ligandsa

aPlasma and brain concentration–time profiles of 8a (A), 8b (B), 8c (C), 8d (D), 13c (E), and 8m (F) after IP administration of a 10 mg kg−1 dose (n = 3 per time point). Cmax = maximum concentration in brain or plasma; tmax = time of maximum concentration in brain or plasma; t1/2 = terminal elimination half-life; AUC0–12 = area under the concentration versus time curve from zero to last measurable time point.