Table 3:

Metabolic Stability in the Presence of HLM and MLM^a

Compound	Half-life (HLM) (hr)	% left after 1 hr. (HLM)	Half-life (MLM) (hr)	% left after 1 hr. (MLM)
8ap	3.6 ± 0.6	86.10 ± 0.71	3.2 ± 0.1	80.35 ± 0.10
8bb,p	8.7 ± 0.6	91.69 ± 0.09	10.5 ± 0.9	92.80 ± 0.07
8cb,p	11.1 ± 3.6	92.00 ± 0.21	14.3 ± 2.8	93.17 ± 0.11
8db,p	13.0 ± 3.0	91.51 ± 0.13	14.1 ± 3.2	93.08 ± 0.14
8eb,m	7.7 ± 1.1	89.50 ± 0.14	9.9 ± 1.9	90.50 ± 0.15
8fb,o	9.9 ± 1.5	90.50 ± 0.14	13.9 ± 4.2	92.00 ± 0.18
8gb,m	3.9 ± 0.3	81.28 ± 0.15	14.5 ± 4.2	91.56 ± 0.23
8hb,o	3.5 ± 0.2	79.92 ± 0.14	10.9 ± 1.5	93.04 ± 0.09
13ab,e	13.2 ± 2.2	92.85 ± 0.10	2.3 ± 0.1	74.77 ± 0.09
13bb,e	9.9 ± 1.1	92.58 ± 0.09	10.7 ± 1.2	92.39 ± 0.09
13cb,e	12.5 ± 3.1	92.30 ± 0.10	9.2 ± 0.9	91.38 ± 0.09
13db,e	9.8 ± 2.8	90.00 ± 0.32	14.5 ± 4.8	92.50 ± 0.23
13ib,f	10.6 ± 2.7	91.00 ± 0.20	12.0 ± 4.0	93.00 ± 0.30
8im	3.4 ± 0.2	81.44 ± 0.16	1.5 ± 0.1	59.83 ± 0.17
8jc,m	10.8 ± 1.0	93.00 ± 0.09	2.8 ± 0.1	76.59 ± 0.08
8kc,p	2.3 ± 0.1	72.50 ± 0.11	1.9 ± 0.1	69.20 ± 0.11
8lc,p	10.7 ± 1.5	92.20 ± 0.15	4.4 ± 0.3	85.54 ± 0.05
8mc,o	16.5 ± 1.8	94.80 ± 0.07	16.6 ± 2.0	94.91 ± 0.07
13ec,e	8.5 ± 0.5	91.60 ± 0.10	4.4 ± 0.2	85.62 ± 0.08
13fc,e	12.1 ± 1.9	93.00 ± 0.12	4.2 ± 0.2	85.11 ± 0.07
8np	1.7 ± 0.1	66.86 ± 0.13	1.9 ± 0.1	68.96 ± 0.12
8od,p	3.4 ± 0.1	81.50 ± 0.11	2.3 ± 0.1	73.85 ± 0.11
8pd,m	1.8 ± 0.1	63.50 ± 0.32	3.6 ± 0.3	79.50 ± 0.20
8qd,o	14.2 ± 3.0	92.85 ± 0.11	1.5 ± 0.3	61.31 ± 0.15
13gd,e	12.1 ± 1.4	93.40 ± 0.11	11.4 ± 1.4	93.13 ± 0.09
13hd,e	38.6 ± 7.7	97.80 ± 0.06	70.8 ± 25.8	98.39 ± 0.04

^aCompounds were incubated with HLM or MLM for 60 minutes and quantified by LC-MS/MS.

^b8a related analogs in red.

^c8i related analogs in blue.

^d8n related analogs in green.

^eD-ring N-hetero analogs.

^fA-ring N-hetero analogs.

^oD-ring “ortho”.

^mD-ring “meta”.

^pD-ring “para”.