Figure 6.

Interaction of sucralose Cl sites and water. (A) Radial distribution functions of water hydrogens and sucralose Cl sites. (B) Same functions as in (A), as a function of a reduced distance r* = r × (σ_Ow/σ_Cl). This reduced scale evidences the presence of water hydrogens at a distance from the Cl ones comparable with the OH distance typical of hydrogen bonding. (C) Radial distribution functions of water oxygens and sucralose Cl sites. The dashed line indicates the position of the first peak on the same reduced scale as in (B). (D) Number of contacts between water and Cl sites on sucralose, corresponding to the first neighbor peak.