Table 4. Antimicrobial Screening of 4-Oxo-6-aryl-2-thioxo-1,2,3,4-Tetrahydropyrimidine-5-carbonitriles (4a–t)^a.

	minimum inhibitory concentration (MIC) in μg/mL
compound	E. c. MTCC (443)	P. a. MTCC (1688)	S. a. MTCC (96)	S. p. MTCC (442)	C. a. MTCC (227)	A. n. MTCC (282)
4a	500	100	250	250	100	500
4b	250	500	500	100	500	100
4c	100	100	100	100	500	250
4d	100	200	250	250	500	100
4e	50	25	500	50	500	250
4f	50	12.5	25	250	100	250
4g	500	100	500	250	250	500
4h	100	100	200	250	100	100
4i	12.5	25	100	50	500	250
4j	100	500	100	100	100	25
4k	500	500	500	250	12.5	50
4l	500	250	500	250	50	100
4m	100	100	250	50	50	100
4n	25	100	250	100	500	250
4o	50	100	100	100	500	250
4p	100	200	100	250	500	200
4q	200	100	250	200	100	100
4r	500	200	200	250	100	250
4s	250	500	100	500	250	100
4t	50	50	200	200	250	100
ampicillin	100	100	250	100
griseofulvin					500	100

^aE. c., Escherichia coli; P. a., Pseudomonas aeruginosa; S. a.,Staphylococcus aureus; S. p., Streptococcus pyogenes; C.a., Candida albicans; A. n., Aspergillus niger.