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. 2020 Jan 1;109(1):1–13. doi: 10.1016/j.xphs.2019.08.001

Table 2.

Composition and Osmolality Values of 8 Candidate Frozen Liquid Formulations for Each NRRV Antigen for Their Individual Bulk Storage

F # Formulation Components (pH 7.2) Osmolality (mOsm)
1 1 mM sodium phosphate +150 mM NaCl (current bulk formulation) 270 ± 1
2 1 mM sodium phosphate +150 mM NaCl +0.025% PS-80 268 ± 1
3 1 mM sodium phosphate +10% w/v sucrose +0.025% PS-80 328 ± 2
4 5 mM sodium phosphate +150 mM NaCl +0.025% PS-80 297 ± 4
5 5 mM sodium phosphate +10% w/v sucrose +0.025% PS-80 330 ± 8
6 1 mM sodium phosphate +7.5% w/v sucrose +50 mM NaCl +0.025% PS-80 343 ± 4
7 5 mM sodium phosphate +7.5% w/v sucrose +50 mM NaCl +0.025% PS-80 308 ± 4
8 5 mM HEPES +10% w/v sucrose +0.025% PS-80 308 ± 4
9 5 mM HEPES +7.5% w/v sucrose +50 mM NaCl +0.025% PS-80 331 ± 2

Osmolality values are from triplicate measurements and error bars represent 1 SD.