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Beneficial and detrimental effects of mutations by ANOVA testing. Analysis of variance first-order effects identified for each of the 5 mutations on the 3 conformational stability measures and the 2 “detrimental” species seen in SEC (oligomer and dimer.) Each mutation’s effects are shown as the standard deviation (bars) and range (whiskers) in residuals and measured effect as an offset from the mean of the parental assay response (mean assay response without the given mutation).
