Table 2.
Round 2 Molecule Sets
| Molecule Seta | Light Chain | Heavy Chain |
|---|---|---|
| MS-194b | ||
| nMS-225 | LmdV:Y2P | HV:V79T |
| MS-226 | LmdV:Y2P | HV:R82V |
| MS-227 | LmdV:Y2P | HV:L89F |
| MS-228 | LmdV:Y2P | HV:T108R |
| MS-229 | HV:V79T, HV:R82V | |
| MS-230 | HV:V79T, HV:L89F | |
| MS-231 | HV:V79T, HV:T108R | |
| MS-232 | HV:R82V, HV:L89F | |
| MS-233 | HV:R82V, HV:T108R | |
| MS-234 | HV:L89F, HV:T108R | |
| MS-235 | LmdV:Y2P | HV:V79T, HV:R82V |
| MS-236 | LmdV:Y2P | HV:V79T, HV:L89F |
| MS-237 | LmdV:Y2P | HV:V79T, HV:T108R |
| MS-238 | LmdV:Y2P | HV:R82V, HV:L89F |
| MS-200 | LmdV:Y2P | HV:R82V, HV:T108R |
| MS-239 | LmdV:Y2P | HV:L89F, HV:T108R |
| MS-240 | HV:V79T, HV:R82V, HV:L89F | |
| MS-241 | HV:V79T, HV:R82V, HV:T108R | |
| MS-201 | HV:V79T, HV:L89F, HV:T108R | |
| MS-242 | HV:R82V, HV:L89F, HV:T108R | |
| MS-243 | LmdV:Y2P | HV:V79T, HV:R82V, HV:L89F |
| MS-244 | LmdV:Y2P | HV:V79T, HV:R82V, HV:T108R |
| MS-202 | LmdV:Y2P | HV:V79T, HV:L89F, HV:T108R |
| MS-245 | LmdV:Y2P | HV:R82V, HV:L89F, HV:T108R |
| MS-246 | HV:V79T, HV:R82V, HV:L89F, HV:T108R | |
| MS-247 | LmdV:Y2P | HV:V79T, HV:R82V, HV:L89F, HV:T108R |
a
All variants including the MS-194 contain the Xtend mutation (LS) in the Fc of the heavy chain.
b
MS-194 is also referred to as parental (+LS) in the manuscript.