Fig. 4.

Window size over which protein stickiness best correlates with protein abundance. (a) The window-averaged, local stickiness (ω^k) is calculated for windows of increasing size (k), represented here as funnels, sliding over the sequence of each protein. The local stickiness corresponds to the average of amino acid scores within a window of k residues (see Methods for details). For each window size, the maximum local average stickiness Ω^k is correlated against protein abundance. Scatterplots for selected values of k (3, 11, 101, 1001) are shown along with the corresponding Spearman rank correlation coefficient (ρ_k). (b) The Spearman rank correlation coefficient (ρ_k) is reported against increasing window sizes (k) considering residues within disordered regions of yeast proteins among the standard, medium, and high disorder-content data sets.