Figure 2.

Effects of Synapse Location on Rate- and Timing-Dependent Plasticity

(A) Stimulation protocol (Sjöström et al., 2001) (inset) and postsynaptic voltage profile of the neuron model with five somatic spikes (50 Hz) starting at time 10 ms. Voltage profile is shown as a function of time and location along one specific path from the soma into the apical dendrite.

(B) Model results as relative weight changes (lines) when fit to experimental data (filled circles, mean ± SEM) at a proximal location (90 μm in the model; left) and at a distal location (669 μm in the model; right) for different intra-burst frequencies. Pre- and postsynaptic bursts were shifted by either +10 ms (blue) or −10 ms (red). Experimental data was recreated from Sjöström et al. (2001) Figure 1D and Figure 7B and from Sjöström and Häusser (2006) Figure 3 (by using the exponential fit of inset data).

(C) Spatiotemporal plasticity windows showing relative weight changes (color coded) as a function of burst timing (x axis) and distance from the soma (y axis; see cell morphology on the left). Synaptic weight changes were calculated at 41 different locations and 101 different timings.

See also Figure S2.