Table 2.
Frequently mutated human cancer genes and their mutations in syngeneic models of the same cancer type
| Human Cancer | Human Gene (a) | Human Mutation Frequency | Model | Model Mutation | Model | Model Mutation |
|---|---|---|---|---|---|---|
| BRCA | PIK3CA | 32.48 | 4T1 | NA | EMT6 | NA |
| BRCA | TP53 | 30.65 | 4T1 | p.Glu32fs | EMT6 | NA |
| BRCA | CDH1 | 11.41 | 4T1 | NA | EMT6 | NA |
| COAD | APC | 71.62 | CT26 | NA | MC38 | NA |
| COAD | TP53 | 53.6 | CT26 | NA | MC38 |
p.Gly242Val p.Ser258Ile |
| COAD | KRAS | 43.24 | CT26 |
p.Gly12Asp p.Val8Met |
MC38 | NA |
| COAD | FBXW7 | 17.12 | CT26 | NA | MC38 | NA |
| COAD | PIK3CA | 14.86 | CT26 | NA | MC38 | NA |
| COAD | SMAD4 | 11.71 | CT26 | NA | MC38 | p.Gly351Arg |
| COAD | ATM | 11.26 | CT26 | NA | MC38 | NA |
| SKCM | BRAF | 51.23 | B16F10 | NA | ||
| SKCM | NRAS | 26.7 | B16F10 | NA | ||
| SKCM | ROS1 | 17.98 | B16F10 | NA | ||
| SKCM | ERBB4 | 16.35 | B16F10 | NA | ||
| SKCM | TP53 | 15.26 | B16F10 | p.Asn128Asp | ||
| SKCM | KDR | 13.35 | B16F10 | NA | ||
| SKCM | NF1 | 12.81 | B16F10 | NA | ||
| SKCM | CDKN2A | 12.26 | B16F10 | NA | ||
| LUSC | TP53 | 81.46 | LLCsr |
p.Glu32* p.Arg334Pro |
||
| LUSC | PIK3CA | 15.17 | LLCsr | NA | ||
| LUSC | CDKN2A | 14.04 | LLCsr | NA | ||
| LUSC | NF1 | 11.8 | LLCsr | NA | ||
| LUSC | ROS1 | 10.67 | LLCsr | NA | ||
| KIRC | VHL | 49.89 | RENCA | NA |
aGenes from TARGET database with at least 10% mutation frequency in TCGA samples
BRCA Breast invasive carcinoma, COAD Colon adenocarcinoma, SKCM Skin cutaneous Melanoma, LUSC Lung squamous cell carcinoma, KIRC Kidney renal clear cell carcinoma