. 2020 Jan 3;10:1. doi: 10.1186/s13601-019-0303-6

Table 9.

Summary of the evidence for ‘efficacy of systemic steroids in sinonasal disease + concomitant asthma

Study	LOE (1a to 5)	Study design	Study groups	Clinical endpoints efficacy	Conclusion
Ikeda et al. [99]	3	Prospective RCT	Adult CRSwNP and CRSsNP patients undergoing ESS	1. Sinonasal and pulmonary symptoms 2. Systemic GCS need	1. Improvement of FEV₁ 2. No significant changes in systemic GCS need

Study

LOE (1a to 5)

Study design

Study groups

Clinical endpoints efficacy

Conclusion

Ikeda et al. [99]

Prospective RCT

Adult CRSwNP and CRSsNP patients undergoing ESS

1. Sinonasal and pulmonary symptoms

2. Systemic GCS need

1. Improvement of FEV₁

2. No significant changes in systemic GCS need

RCT randomized controlled trial, CRS chronic rhinosinusitis, CRSsNP chronic rhinosinusitis without nasal polyps, CRS chronic rhinosinusitis, CRSwNP chronic rhinosinusitis with nasal polyps, GCS glucocorticosteroids