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. 2020 Jan 2;22:2. doi: 10.1186/s13075-019-2086-5

Table 4.

Differential expression of the miRNA level in the serum from controls and OA patients, analyzed by next-generation sequencing

Names Log2 fold change p value FDR adjusted p value Healthy average TPM OA average TPM
hsa-miR-139-5p 0.73 0.0001 0.0434 90.1 143.3
hsa-miR-1299 − 3.38 0.0002 0.0434 12 0.8
hsa-miR-200a-3p − 1.88 0.0003 0.0473 77.2 29.4
hsa-miR-129-5p 0.81 0.0022 0.1640 3.6 6.5
hsa-miR-429 − 1.43 0.0023 0.1640 5.5 2.5
hsa-miR-9-5p 0.83 0.0045 0.2410 3.2 6.1
hsa-miR-375 − 0.93 0.0065 0.2795 737 411.3
hsa-miR-139-3p 0.61 0.0072 0.2820 48.8 69.7
hsa-miR-200b-3p − 1.18 0.0089 0.3193 28 15.7
hsa-miR-150-5p 0.72 0.0164 0.4619 173.6 252.6
hsa-miR-192-5p − 1.03 0.0171 0.4619 1837.8 1161.9
hsa-miR-155-5p 0.52 0.0193 0.4907 64.9 87.5
hsa-miR-15b-3p − 0.73 0.0247 0.5867 43.8 24.3
hsa-miR-1228-5p 0.78 0.0295 0.5918 4.9 8.7
hsa-miR-126-3p 0.38 0.0304 0.5918 3243.9 3976.7
hsa-miR-206 1.10 0.0338 0.6011 51.3 95.9
hsa-miR-199b-5p − 0.57 0.0373 0.6011 29.9 18.6
hsa-miR-1246 0.67 0.0375 0.6011 29.9 46.9
hsa-miR-10b-5p 0.46 0.0428 0.6390 3848.4 5039.8
hsa-miR-642a-3p 0.69 0.0444 0.6405 4.5 7.2
hsa-miR-186-5p − 0.45 0.0473 0.6405 777.7 534
hsa-miR-10a-5p 0.45 0.0493 0.6469 2613.1 3361.1

When we compared the OA vs healthy groups, 22 miRNAs showed differential expression (p < 0.05) between controls and OA patients. After Benjamini-Hochberg false discovery rate (FDR) correction, hsa-miR-139-5p, hsa-miR-1299, and hsa-miR-200a-3p remained significantly different between OA patients and controls (p < 0.05, FDR at 5%)