Fig. 1.

Frequency of immune cell types in patients with CML receiving TKIs, either alone or in combination with IFN-α, and in healthy controls. a Pie charts summarizing the distribution of T cells, CD4⁺ and CD8⁺ major subsets, and NK cells in the blood of CML patients and healthy controls. T_CM = central memory T cell; T_EM = effector memory T cell; T_EMRA = terminally differentiated, effector memory T cell. b Serum IL-21 levels in a subgroup of patients receiving either TKIs alone of TKIs in combination with IFN-α, and in healthy controls. Results were compared with one-way ANOVA with Tukey’s multiple comparisons test