Table 4:

The Clinical Status at Each Study Day it was Assessed

Study Day	Randomized treatment	N	Death	In the ICU	Non-ICU hospitalization, requiring supplemental oxygen	Non-ICU hospitalization, not requiring supplemental oxygen	Not hospitalized, but unable to resume normal activity	Not hospitalized, with full resumption of normal activity	Missing	Odds ratio **	95% CI	p-value
0	High titre	91		40 (44%)	37 (41%)	14 (15%)
	Low titre	47		20 (43%)	18 (38%)	9 (19%)
1	High titre	91		38 (42%)	30 (33%)	21 (23%)	2 (2%)		0	0.86	[0.45, 1.66]	0.66
	Low titre	46		18 (39%)	14 (30%)	14 (30%)	0 (0%)		1
2	High titre	91	1 (1%)	35 (38%)	24 (26%)	19 (21%)	6 (7%)	6 (7%)	0	0.95	[0.50, 1.80]	0.87
	Low titre	46	0 (0%)	17 (37%)	12 (26%)	13 (28%)	3 (7%)	1 (2%)	1
3	High titre	90	1 (1%)	29 (32%)	20 (22%)	17 (19%)	11 (12%)	12 (13%)	1	1.26	[0.65, 2.41]	0.49
	Low titre	43	0 (0%)	15 (35%)	10 (23%)	12 (28%)	4 (9%)	2 (5%)	4
7	High titre	91	2 (2%)	15 (16%)	16 (18%)	8 (9%)	30 (33%)	20 (22%)	0	1.22	[0.65, 2.29]	0.54
	Low titre	46	2 (4%)	10 (22%)	7 (15%)	5 (11%)	11 (24%)	11 (24%)	1
14	High titre	86	4 (5%)	10 (12%)	3 (3%)	6 (7%)	26 (30%)	37 (43%)	5	1.07	[0.55, 2.08]	0.83
	Low titre	45	4 (9%)	6 (13%)	2 (4%)	1 (2%)	12 (27%)	20 (44%)	2
28	High titre	88	6 (7%)	5 (6%)	0 (0%)	2 (2%)	24 (27%)	51 (58%)	3	1.29	[0.65, 2.56]	0.47
	Low titre	45	4 (9%)	3 (7%)	2 (4%)	1 (2%)	11 (24%)	24 (53%)	2

^**Proportional odds model

NOTE: an odds ratio of greater than one is indicative of improved clinical status for the high-titre group versus the low-titre group