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. 2020 Jan 2;20:3. doi: 10.1186/s12885-019-6465-8

Fig. 5.

Fig. 5

Formation of sarcomas after injection of mice with MSCs in Matrigel carrier. a Tumor formation (arrow) in the quadriceps muscle is shown after injection of 1 × 106 Stag2 shRNA+10Gy cells (irradiated MSCs with Stag2 knockdown, EWS-FLI1 expression, and p53−/− null mutation). b Histopathology shows a pleomorphic spindle cell sarcoma with frequent mitotic figures. c The rate of tumor formation is significantly higher for Stag2 shRNA+10Gy compared to Ctrl shRNA+10Gy cells (p < .001). d Kaplan-Meier survival is significantly shorter for mice injected with Stag2 shRNA+10Gy compared to Ctrl shRNA+10Gy cells (p < .001)