Table 3:
Mean percentage difference (95% CI) in inflammatory markers, by early-life adversities
| 1958 British birth cohort | MIDUS | |||||
|---|---|---|---|---|---|---|
| CRP | Fibrinogen | CRP | Fibrinogen | IL6 | ||
| Neglect | Model 11 | 31.3 (22.2,40.5) | 4.72 (3.19,6.25) | |||
| Model 22 | 23.8 (14.4,33.1) | 3.67 (2.10,5.24) | ||||
| Emotional neglect | Model 11 | 4.75 (−3.70,13.2) | 1.35 (−0.08,2.78) | 20.5 (−7.56, 48.6) | 5.23 (−0.75, 11.2) | 9.76 (−6.83, 26.4) |
| Model 22 | 2.28 (−6.13,10.7) | 1.00 (−0.42,2.43) | 17.6 (−10.9, 46.1) | 4.88 (−1.14, 10.9) | 6.75 (−10.3, 23.8) | |
| Physical abuse | Model 11 | 23.0 (11.7,34.3) | 3.92 (2.00,5.84) | 26.8 (−3.59, 57.3) | 6.66 (−0.29, 13.6) | 16.8 (−5.21, 38.8) |
| Model 22 | 20.0 (8.75,31.2) | 3.46 (1.55,5.37) | 23.2 (−7.59, 54.0) | 6.18 (−0.75, 13.1) | 13.0 (−9.20, 35.1) | |
| Psychological abuse | Model 11 | 13.9 (4.75,23.0) | 2.77 (1.23,4.31) | 9.89 (−15.0, 34.8) | 5.99 (1.16, 10.8) | 7.22 (−7.99, 22.4) |
| Model 22 | 11.6 (2.51,20.6) | 2.44 (0.90,3.98) | 7.26 (−17.6, 32.1) | 5.37 (0.53, 10.2) | 5.59 (−9.83, 21.0) | |
| Sexual abuse3 | ||||||
| White participants | Model 11 | 14.8 (−6.64,36.1) | 1.97 (−1.66,5.59) | 31.6 (6.17, 57.0) | 5.91 (0.35, 11.5) | 19.5 (3.62, 35.5) |
| Model 22 | 8.56 (−12.7,29.8) | 1.20 (−2.42,4.81) | 16.7 (−11.4, 44.8) | 1.62 (−4.59, 7.83) | 9.89 (−7.44, 27.2) | |
| Non-white participants | Model 11 | 59.2 (7.90, 110) | 13.2 (2.47, 23.9) | 38.0 (6.41, 69.5) | ||
| Model 22 | 57.9 (6.61, 109) | 14.1 (3.39, 24.9) | 36.3 (4.64, 68.0) | |||
| Childhood socioeconomic disadvantage | Model 11 | 20.8 (12.2,29.5) | 2.13 (0.66,3.60) | 2.64 (−16.7, 22.0) | 0.30 (−3.67, 4.26) | 6.23 (−6.15, 18.6) |
| Model24 | 20.7 (12.0,29.3) | 2.18 (0.71,3.65) | 2.93 (−16.3, 22.2) | 0.34 (−3.65, 4.33) | 6.13 (−6.18, 18.4) | |
1
adjusted for age, race and gender
2
additionally adjusted for season and childhood socioeconomic disadvantage (as a continuous variable)
3
MIDUS: p-value for race interaction for CRP, fibrinogen and IL-6: 0.09, 0.06 and 0.04 respectively
4
additionally adjusted for season