Table 4:
Mean percentage difference (95% CI) in inflammatory markers by mutually adjusted early-life adversities
| 1958 British birth cohort | MIDUS | |||||
|---|---|---|---|---|---|---|
| CRP | Fibrinogen | CRP | Fibrinogen | IL6 | ||
| Neglect | Model 11 | 23.2 (13.8,32.6) | 3.51 (1.93,5.09) | |||
| Model 22 | 23.2 (13.7,32.6) | 3.53 (1.95,5.12) | ||||
| Model 33 | 16.3 (8.14,24.4) | 2.78 (1.27,4.29) | ||||
| Model 44 | 17.7 (8.18,27.2) | 2.66 (1.06,4.26) | ||||
| Emotional neglect | Model 11 | −3.82 (−12.7,5.07) | −0.07 (−1.58,1.44) | 11.7 (−18.3, 41.7) | 2.43 (−3.73, 8.59) | 2.41 (−15.9, 20.7) |
| Model 22 | −3.74 (−12.6,5.15) | −0.05 (−1.56,1.46) | 12.1 (−17.9, 42.2) | 2.64 (−3.43, 8.72) | 2.53 (−15.8, 20.8) | |
| Model 33 | 0.41 (−7.44,8.27) | 0.42 (−1.01,1.86) | 8.90 (−17.9, 35.7) | 2.33 (−3.47, 8.14) | 0.04 (−16.7, 16.7) | |
| Model 44 | −4.65 (−13.5,4.21) | −0.20 (−1.70,1.31) | 10.5 (−19.5, 40.4) | 2.33 (−3.71, 8.38) | 1.01 (−16.6, 18.7) | |
| Physical abuse | Model 11 | 16.1 (2.81,29.5) | 2.42 (0.15,4.68) | 16.3 (−17.2, 49.7) | 2.62 (−5.38, 10.6) | 9.22 (−15.5, 33.9) |
| Model 22 | 16.3 (3.01,29.7) | 2.40 (0.13,4.66) | 17.0 (−16.4, 50.3) | 2.88 (−5.04, 10.8) | 9.07 (−15.7, 33.9) | |
| Model 33 | 8.41 (−3.37,20.2) | 1.55 (−0.61,3.71) | 15.1 (−14.4, 44.7) | 2.61 (−5.05, 10.3) | 8.51 (−14.7, 31.7) | |
| Model 44 | 16.0 (2.74,29.3) | 2.35 (0.09,4.60) | 13.0 (−20.2, 46.3) | 2.21 (−5.68, 10.1) | 5.64 (−18.7, 30.0) | |
| Psychological abuse | Model 11 | 5.17 (−5.80,16.1) | 1.38 (−0.49,3.24) | −6.01 (−33.6, 21.6) | 3.37 (−2.04, 8.78) | −1.67 (−19.0, 15.7) |
| Model 22 | 5.09 (−5.88,16.1) | 1.37 (−0.50,3.23) | −6.83 (−34.4, 20.7) | 2.89 (−2.50, 8.29) | −1.23 (−18.8, 16.3) | |
| Model 33 | 5.91 (−3.78,15.6) | 1.47 (−0.31,3.24) | −7.25 (−31.2, 16.7) | 2.77 (−2.49, 8.02) | −1.03 (−17.2, 15.1) | |
| Model 44 | 5.00 (−5.93,15.9) | 1.35 (−0.50,3.21) | −6.35 (−34.1, 21.4) | 2.99 (−2.40, 8.37) | −0.79 (−18.2, 16.7) | |
| Sexual abuse5 | ||||||
| (white participants) | Model 11 | −2.10 (−24.0,19.8) | −0.94 (−4.67,2.78) | 10.4 (−17.7, 38.6) | 0.38 (−5.76, 6.52) | 7.90 (−9.34, 25.1) |
| Model 22 | −2.61 (−24.5,19.3) | −0.89 (−4.61,2.84) | 11.1 (−17.0, 39.1) | 0.33 (−5.79, 6.45) | 8.14 (−9.04, 25.3) | |
| Model 33 | −0.45 (−19.9,19.0) | −0.63 (−4.18,2.91) | −12.7 (−37.3, 12.0) | −2.46 (−8.29, 3.37) | −4.29 (−18.8, 10.2) | |
| Model 44 | −6.16 (−28.0,15.7) | −1.45 (−5.16,2.26) | 9.15 (−18.8, 37.1) | −0.06 (−6.17, 6.05) | 6.66 (−10.2, 23.6) | |
| (non-white participants) | Model 11 | 75.5 (20.5, 130) | 13.6 (2.02, 25.1) | 33.9 (0.12, 67.7) | ||
| Model 22 | 72.4 (17.7, 127) | 13.5 (1.97, 25.1) | 32.3 (−1.44, 66.1) | |||
| Model 33 | 24.8 (−24.5, 74.1) | 6.22 (−4.82, 17.3) | 10.3 (−22.4, 42.9) | |||
| Model 44 | 71.2 (16.6, 125) | 13.4 (1.82, 24.9) | 31.0 (−2.41, 64.4) | |||
| Childhood socioeconomic disadvantage | Model 11 | 16.4 (7.64,25.1) | 1.40 (−0.09,2.89) | −3.44 (−23.2, 16.4) | −1.12 (−5.19, 2.96) | 2.79 (−9.98, 15.6) |
| Model 22 | 16.2 (7.50,24.9) | 1.44 (−0.05,2.94) | −3.19 (−22.9, 16.6) | −1.08 (−5.18, 3.02) | 2.67 (−10.0, 15.4) | |
| Model 33 | 5.05 (−2.70,12.8) | 0.24 (−1.18,1.66) | −4.49 (−22.1, 13.1) | −1.26 (−5.12, 2.59) | 2.16 (−9.80, 14.1) | |
| Model 44 | 13.2 (4.47,22.0) | 0.97 (−0.52,2.47) | −5.52 (−25.4, 14.3) | −1.51 (−5.61, 2.59) | 0.53 (−12.0, 13.1) | |
Childhood socioeconomic disadvantage entered as binary variable, when it is the exposure of interest; otherwise entered as a continuous variable.
1
adjusted for age, race, gender and simultaneously for other types of early-life adversities
2
additionally adjusted for season
3
Model 2 + adjustment for BMI and WHR (in 1958 cohort modelled with a gender interaction)
4
Model 2 + adjustment for adult socioeconomic disadvantage (range:0-10)
5
MIDUS: p-value for race interaction for CRP, fibrinogen and IL-6: 0.10, 0.09 and 0.05 respectively.