Skip to main content
. 2020 Jan 2;19:1. doi: 10.1186/s12936-019-3075-5

Table 10.

Physicochemical and pharmacokinetic properties for selected anti-malarials

Property 8-Aminoquinolines Peroxides
Primaquinea Tafenoquinea DHAb OZ277b OZ439b
Log D7.4 0.54 4.24 2.3 2.6 > 5
Plasma fu 0.26 0.0007 0.21 0.086 < 0.0001
FaSSGF solubility (µg/mL) > 2000 > 2000 140 > 2000 79
FaSSIF solubility (µg/mL) > 2000 15.8 159 > 2000 40.6
FeSSIF solubility (µg/mL) > 2000 1310 246 > 2000 526
Half-life (h) 7 360 1 3 > 40
V/F (L) 277 1600 385 929 1570
CL/F (L/h) 28 3.0 272 184 41
Food effect no yes no no yes

aPharmacokinetic data for TQ from [82] and PQ from [83]

bPharmacokinetic data for DHA from [84], OZ277 from [85], and OZ439 from [70]