Table 7.

Whole blood to plasma partitioning

Compound	B/Pa	Haematocrit (Gender)
Ionized or partially ionized bases at physiological pH
Cycloguanil	0.71 ± 0.07	0.48 (M)
Doxycyclin	0.78 ± 0.06	0.43 (M)
Pyronaridine	9.0 ± 0.83	0.48 (M)
Proguanil	3.30 ± 0.14	0.46 (M)
Primaquine	0.82 ± 0.07	0.44 (M)
Chloroquine	3.5 ± 0.09	0.42 (F)
Chlorproguanil	3.3 ± 0.38	0.43 (M)
Azithromycin	1.6 ± 0.19	0.48 (M)
AQ-13	3.15 ± 0.20	0.42 (M)
Desethylamodiaquine	3.26 ± 0.35	0.50 (M)
Quinine	0.67 ± 0.02	0.44 (M)
Clindamycin	0.61 ± 0.04	0.42 (M)
KAF156	1.3 ± 0.02	0.42 (F)
M5717	1.3 ± 0.02	0.42 (F)
OZ277	1.10 ± 0.10	0.46 (M)
Mefloquine	1.1 ± 0.07	~ 0.43 (M)
Amodiaquine	1.1 ± 0.18	~ 0.43 (M)
NPC1161B	1.09 ± 0.07	0.44 (M)
Ferroquine	1.6 ± 0.15	~ 0.43 (M)
Naphthoquine	1.14 ± 0.10	~ 0.43 (M)
Tafenoquine	1.3 ± 0.04	~ 0.43 (M)
MMV253	1.0 ± 0.05	~ 0.43 (M)
MMV052	1.6 ± 0.14	~ 0.43 (M)
Piperaquine	0.57 ± 0.05	~ 0.43 (M)
Halofantrine	0.68 ± 0.06	0.43 (M)
TDD-E209	0.51 ± 0.08	0.44 (M)
Lumefantrine	0.48 ± 0.09	0.48 (M)
Ionized acids at physiological pH
Sulfadoxine	0.57 ± 0.03	0.46 (M)
Sulfamethoxazole	0.65 ± 0.07	0.43 (M)
Artesunate	CNDb	0.44 (M)
Atovaquone	0.52 ± 0.03	0.44 (M)
Zwitterionic or partially zwitterionic at physiological pH
P218	0.56 ± 0.03	~ 0.43 (M)
JPC3210	0.54 ± 0.04	~ 0.43 (M)
Neutral at physiological pH
Dapsone	1.1 ± 0.06	0.43 (M)
Dihydroartemisinin	CNDb	0.42 (M)
DSM421	0.53 ± 0.03	0.44 (M)
Pyrimethamine	0.84 ± 0.03	0.43 (M)
MMV048	0.77 ± 0.03	0.42 (F)
Artemisone	CNDb	0.44 (M)
Artemether	CNDb	0.42 (M)
SJ733	0.72 ± 0.02	0.42 (F)
DSM265	0.54 ± 0.02	0.44 (M)
KAE609	0.66 ± 0.04	0.42 (F)
OZ439	0.78 ± 0.05	0.44 (M)
ELQ300	0.53 ± 0.05	0.44 (M)

^aMean ± SD, n = 3–4 measurements

^bCND = could not determine, unstable in blood and plasma