Fig. 2.

Two exemplar applications of the framework to individuals with good and bad postsurgical outcome. (A) Patient FR 253 had a bilateral intracranial electrode implantation (see black dots), and the performed surgery targeted a region in the right hemisphere (not represented). The patient achieved a good postsurgical outcome (Engel Ia). Four seizures recorded from scalp EEG were analyzed using our framework and two candidate regions for resection were identified in the right hemisphere (superior parietal and supramarginal; regions highlighted in green), concordant with the hemisphere where surgery was performed. (B) Patient FR 273 had intracranial electrodes implanted in the left hemisphere, and the performed surgery targeted a region in the left hemisphere. The postsurgical outcome was poor (Engel IIIa). In this case we studied five seizures and each of them identified a different possible candidate region for resection (regions highlighted in blue). Such inconclusive result from scalp EEG would support a bilateral electrode implantation. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)