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. 2015 Mar 27;3(1):e38. doi: 10.15190/d.2015.30

Table 2. Inflammatory markers in blood circulation.

Type Comments References
Cells
CD3+CD4+CD69+ T cells Independent prognostic factor for overall survival 59
CD19+ B lymphocytes High levels found in patients with advanced stage 31
Peripheral NK cells Increased in metastatic melanoma 69,70
Circulating monocytic (Mo)-MDSCs Correlated with disease progression 6
Molecules
LDH Staging and prognosis marker 76
S100B, MIA Common used markers for prognosis and monitoring therapy 80
Serum amyloid A, C reactive protein Acute phase reactant protein 84
Ceruloplasmin Acute phase reactant protein 85
TNFR2, TGF-alpha, TIMP1, CRP Mediators of chronic inflammatory, indicators of immunosuppressive status 86
TNF-alpha, soluble interleukin-2 receptor and beta-2 microglobulin Predictive markers of relapse 87
IL-6, IL-8, TNF-alpha Cytokines, staging markers 31
IL1-beta Marker of metastasis 31
TGF-beta1 Growth factor involved in skin inflammation, marker for diagnosis and prognosis 97
Cytokines IL-4, IL-10, Il-13 and chemokines CCL5(RANTES), CXCL10 High levels of Th2 cytokines in patient plasma with metastatic melanoma 61-63