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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Hepatol. 2019 Oct 10;72(1):146–155. doi: 10.1016/j.jhep.2019.09.030

Figure 3. VWF deficiency does not affect coagulation cascade activation after APAP-induced acute liver injury in mice.

Figure 3.

Wild-type (WT) and VWF−/− (VWF KO) mice were given 300mg/kg APAP or saline (i.p.) and samples were collected 24h, 48h, and 72h later. (A) Thrombin-antithrombin complex (TAT) plasma levels in wild-type (black bars) and VWF−/− (grey bars) mice were determined by ELISA. (B) Quantification of hepatic fibrin(ogen) immunofluorescent labeling, expressed as positive pixel count in wild-type (black bars) and VWF−/− (grey bars) mice challenged with saline or APAP at 24h. (C) Representative images of hepatic fibrin(ogen) immunolabeling (red) in DAPI (blue)-counterstained liver sections. Scale bars = 100 μm. Bars represent mean + standard error of the mean (n = 5-7 mice per group).