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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Hepatol. 2019 Oct 10;72(1):146–155. doi: 10.1016/j.jhep.2019.09.030

Figure 4. VWF prolongs platelet deposition in the APAP-injured liver.

Figure 4.

Wild-type (WT) and VWF−/− (VWF KO) mice were given 300mg/kg APAP or saline (i.p.) and samples were collected 24h, 48h, and 72h later. Representative images showing immunolabeling of CD41 (platelets; red) and VWF (green) in DAPI (blue)-counterstained liver sections from wild-type mice (A) or VWF KO mice (B), colocalization of VWF with platelets is indicated by yellow/orange. Original magnification is 100x. (C) Quantification of platelet deposition in wild-type (black bars) mice and VWF−/− (grey bars) mice, expressed as percentage of positive pixel count at indicated time points. Bars represent mean + standard error of the mean (n = 5-7 mice per group) * p <0.05