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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Hepatol. 2019 Oct 10;72(1):146–155. doi: 10.1016/j.jhep.2019.09.030

Figure 5. VWF deficiency accelerates liver repair after APAP-induced acute liver injury in mice.

Figure 5.

Wild-type (WT) and VWF−/− (VWF KO) mice were given 300mg/kg APAP or saline (i.p.). (A) Serum alanine aminotransferase (ALT) activity. (B) Area of hepatocellular necrosis and (C) Area of hepatic congestion and hemorrhage were determined 24h, 48h, and 72h after APAP challenge. (D) Representative photomicrographs of H&E-stained liver sections depict hepatocellular necrosis (closed triangle) and congestion/hemorrhage (asterisk). (E) Representative photomicrographs of proliferating cell nuclear antigen (PCNA) labeled liver sections various times after APAP challenge. (F) PCNA-positive hepatocytes were quantified as the sum of positive cells in 5 random 200X fields. (G) Hepatic mRNA levels of cell cycle genes. Data are expressed as means + standard error of the mean (n = 5-12 mice per group) * p<0.05.