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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Pediatr Blood Cancer. 2019 Apr 22;66(8):e27770. doi: 10.1002/pbc.27770

Figure 1. Large B-cell lymphoma with IRF4 rearrangement from the tonsil.

Figure 1.

A) H&E 20X of tonsil demonstrating squamous mucosa overlying an atypical lymphoid proliferation. B) H&E 400X demonstrating atypical cells with round to irregular nuclear contours, vesicular chromatin, and prominent nucleoli. C, A subset of atypical lymphocytes expressed weak BCL6 (400X), while (D) >95% of atypical lymphocytes strongly expressed MUM1 (400X). The cells lacked BCL2 and CD10. E) FISH demonstrated separated red and green probes from the IRF4 gene break-apart probe.