Table 1.
Minimum inhibitory concentrations (MICs) of meropenemn and curcumin alone or in combination and fractional inhibitory concentration indices (FICIs) for potentially important pathogens of burn wounds
| Isolate | Genes |
Curcumin
|
meropenem
|
Curcumin-meropenem
|
FICI |
|---|---|---|---|---|---|
| MIC (µg/ml) | |||||
| K. pneumoniae | DHA | 128 | 128 | 32 | 0.5 (ad) |
| P. aeruginosa | VEB | 128 | 128 | 32 | 0.5 (ad) |
| A. baumannii | OXA-23,OXA-24 | 128 | 64 | 16 | 0.37 (S) |
| A. baumannii | OXA-23,OXA-24 | 128 | 128 | 64 | 1 (ad) |
| P. aeruginosa | IMP-1 | 128 | 128 | 64 | 1 (ad) |
| E. faecalis ATCC 29212 | Type strain | 128 | 8 | 2 | 0.26 (S) |
| P. aeruginosa | GES | 128 | 64 | 32 | 0.75 (ad) |
| A. baumannii | OXA-23,OXA-24 | 512 | 16 | 4 | 0.25 (S) |
| A. baumannii ATCC19606 | Type strain | 512 | 1 | 0.5 | 0.5 (ad) |
| A. baumannii | OXA-23,OXA-24 | 512 | 16 | 4 | 0.25 (S) |
| P. aeruginosa | IMP-1 | 512 | 128 | 8 | 0.064 (S) |
| P. aeruginosa | VIM-1 | 512 | 128 | 8 | 0.064 (S) |
| E. coli ATCC 25922 | Type strain | 256 | 0.025 | 0.01 | 0.4 (S) |
| K. pneumoniae ATCC 700603 | Type strain | 256 | 1 | 0.5 | 0.5 (ad) |
| K. pneumoniae | NDM-6 | 256 | 32 | 8 | 0.28 (S) |
| K. pneumoniae | NDM-1 | 256 | 32 | 16 | 0.56 (ad) |
| K. pneumoniae | NDM-6 | 256 | 32 | 16 | 0.56 (ad) |
| P. aeruginosa | IMP-2 | 256 | 32 | 16 | 0.56 (ad) |
S = synergy, Ad = additive effect.