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. 2019 Dec 30;14:2301–2304. doi: 10.2147/CIA.S235595

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© 2019 Man and Elias.

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Schematic diagram: pathogenic role of epidermal dysfunction in inflammaging and its associated disorders in the elderly. Due to reductions in epidermal lipid production, filaggrin and NHE1/sPLA2 expression, aged humans display multiple functional abnormalities in the epidermis, including delayed permeability barrier recovery, reduced stratum corneum hydration and elevated stratum corneum pH, which all can provoke cutaneous inflammation. In turn, cutaneous inflammation can also induce pruritus, leading to further barrier disruption because of scratching. Because of skin’s vast size, persistent cutaneous inflammation can induce sustained elevation in cytokine levels in the circulation, consequently leading to the development of inflammaging-associated disorders.