Skip to main content
. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: J Biol Inorg Chem. 2019 Nov 5;24(8):1179–1188. doi: 10.1007/s00775-019-01737-3

Fig. 7. Signal dependent and constitutive secretion of DBH.

Fig. 7.

Cu levels in the cytosol of DBH expressing cells are regulated through a coordinated action of two Cu-transporters ATP7A and ATP7B. Both are thought to get their Cu from Cu chaperone Atox1. DBH receives Cu and is activated in the TGN, where it also undergoes partial proteolytic processing and sorting. The major fraction of DBH is sorted towards the secretory granules. The minor fraction is targeted for constitutive export