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Images of 3D MiaPaCa-2 (A) and 3D PPCL-46 (B) cultures after exposure to different concentrations (10 –120 μM) of GemHCl and Gem-SLN15 (at Gem equivalent dose). GemHCl or Gem-SLN15 treated 3D MiaPaCa-2 culture (immortalized established cells) appeared to increase in spheroid volume and surface area compared with 3D PPCL-46 culture (primary patient-derived pancreatic cells). Scale bar = 400 μm. Patient derived pancreatic cancer (PPCa) cells as seen in figure represents PPCL-46.
