Table 3:
Mean particle size, polydispersity index, mean, entrapment efficiency (%EE) and loading efficiency (% LE) of Poloxamer 188
| Formulation | Mean Particle size (nm) | Polydispersity index | Mean Zeta Potential (mV) | % Entrapment Efficiency (% EE) | % Loading Efficiency (% LE) |
|---|---|---|---|---|---|
| Gem-SLN1 | 565 ± 66 | 0.197 ± 0.03 | −27.1 ± 0.5 | 16.5 ± 0.1 | 0.77 |
| Gem-SLN2 | 676 ± 69 | 0.134 ± 0.01 | −25.1 ± 1.3 | 43.5 ± 2.2 | 0.86 |
| Gem-SLN3 | 584 ± 16 | 0.352 ± 0.12 | −23.6 ± 0.2 | 20.0 ± 1.0 | 0.69 |
| Gem-SLN4 | 684 ± 49 | 0.146 ± 0.03 | −22.1 ± 0.9 | 56.6 ± 5.4 | 0.84 |
| Gem-SLN5 | 264 ± 2 | 0.204 ± 0.02 | −29.9 ± 0.9 | ND | NA |
| Gem-SLN6 | 279 ± 8 | 0.192 ± 0.01 | −33.3 ± 0.4 | 47.0 ± 3.6 | 0.85 |
| Gem-SLN7 | 228 ± 5 | 0.109 ±0.01 | −31.4 ± 0.7 | ND | NA |
| Gem-SLN8 | 334 ± 6 | 0.191 ± 0.01 | −29.1 ± 0.3 | ND | NA |
| Gem-SLN9 | 545 ± 20 | 0.395 ± 0.07 | −24.9 ± 0.2 | ND | NA |
| Gem-SLN10 | 470 ± 3 | 0.218 ± 0.04 | −25.0 ± 1.4 | 53.2 ± 2.8 | 0.86 |
| Gem-SLN11 | 518 ± 22 | 0.252 ± 0.01 | −22.4 ± 0.4 | 51.1 ± 2.2 | 0.82 |
| Gem-SLN12 | 459 ± 12 | 0.236 ± 0.11 | −25.8 ± 0.9 | ND | NA |
Data represents mean ± SD, n = 3.
*
ND = Gem was not detected